This report seeks to strengthen the science-policy interface as an evidence-based instrument to support policymakers and other stakeholders in the implementation of the 2030 Agenda across the social, economic, and environmental dimensions of sustainable development. It uses the latest scientific assessments, evidence bases about good practices, and scenarios that link future trajectories to current actions to identify calls to action by a range of stakeholders that can accelerate progress towards achieving the Sustainable Development Goals (SDGs). Those actions derive from knowledge about the interconnections across individual goals and targets, recognizing that the true transformative potential of the 2030 Agenda can be realized only through a systemic approach that helps identify and manage trade-offs while maximizing co-benefits.